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Eggs and sperm are fertilised in the lab; one or more embryos are transferred to the uterus. The main treatment when simpler options have not worked or when age, tubal, or multiple factors are involved.

Washed, prepared sperm is placed in the uterus around ovulation—often after ovulation induction. A common first-line treatment for mild male factor or unexplained infertility.

A single sperm is injected directly into each egg—especially useful for low count, poor motility, or abnormal morphology. Often combined with IVF when male factor is present.